Laboratorios de Investigación y Desarrollo (LID)
Facultad de Ciencias y Filosofía

Departamento de Ciencias Biológicas y Fisiológicas
Sección Fisiología

Dra. María Rivera Chira
Dra. Fabiola León-Velarde Servetto

• Fisiología y fisiopatología cardiorespiratoria en hipoxia aguda y crónica (mal de montaña agudo y mal de montaña crónico).
• Fisiología comparada y adaptativa en hipoxia

Publicaciones (de los últimos 5 años)

1. León-Velarde F., M. Vargas, M. Rivera-Chira y C. Monge C. Futbol y aclimatación a la altura. Acta Andina. 8(1/2): 23-29, 1999/2000.



2. León-Velarde F., A. Gamboa., J.A. Chuquiza, W.A. Esteba, M. Rivera-Ch. and C. Monge C. Hematological parameters in high altitude Andean Residents living at 4355, 4660 and 5500 meters above sea level. High Altitude Med&Biol. 1(2): 97-104, 2000.



3. León-Velarde F., M. Rivera-Chira, J-A. Palacios, R. Tapia, Huicho L., and C. Monge C. Relationship of ovarian hormones to hypoxemia in women resident of 4,300 m.  Am. J. Physiol. Regul. Integr. Comp. Physiol. 280(2): R488-R493, 2001.



4. Vargas, M., D. Jimenez, F. León-Velarde, J. Osorio and J.P. Mortola. Circadian patterns in men acclimatized to intermittent hypoxia. Respir Physiol. 126: 233-243, 2001.



5. Monge C., León-Velarde F., and A. Arregui. Chronic mountain sickness. In: High Altitude. An Exploration of Human Adaptation. Series: Lung Biology in Health and Disease. Edited by C. Lenfant. Marcel Dekker, Inc. N.Y. pp. 815-838, 2001.



6. Gamboa, A., F. León-Velarde, M. Rivera-Ch, M. Vargas, J-A. Palacios and C. Monge C. Ventilatory and cardiovascular responses to hypoxia in Andean natives living at  sea level. High Alt. Med. & Biol. 2(3): 341-349, 2001.



7. Huicho, L., I.G. Pawson, F. León-Velarde, M. Rivera-Chira, A. Pacheco, M. Muro, and J. Silva. Oxygen saturation and heart rate in healthy school children and adolescents living at high altitude.  Am. J. of Hum. Biol. 13:761-770, 2001.



8. León-Velarde F. and J. Reeves. International Working Group for Chronic Mountain Sickness. Meeting Minutes. In: Hypoxia from Genes to the Bedside, Advances in Exp. Med. & Biol. Chapter 28. Vol. 502: 439-440, 2001.



9. Keyl, C., A. Schneider, A. Gamboa, L. Spicuzza, N. Casiraghi, A. Mori, R.
   Tapia Ramirez, F. León-Velarde, L. Bernardi. Modulation of autonomic cardiovascular function in Andean high-altitude natives with and without chronic mountain sickness. J. Appl Physiol. 2003 94(1): 213-219, 2003.



10. Gamboa A, León-Velarde F, Rivera-Ch M, Palacios J-A, Pragnell T.R, O’Connor D. and Robbins P.A. Acute and sustained ventilatory responses to hypoxia in high altitude natives living at sea level. J. Applied Physiol. 94(3): 1255-1262, 2003.



11. Rivera-Ch M, Gamboa A, León-Velarde F, Palacios J-A, O’Connor D. and Robbins P.A. High altitude natives living at sea level acclimatize to high altitude like sea level natives. J. Applied Physiol. 94(3): 1263-1268, 2003.



12. León-Velarde F, Gamboa A, Rivera-Ch M, Palacios J-A, and Robbins P.A. Peripheral chemoreflex function in high altitude natives and patients with chronic mountain sickness. J. Applied Physiol. 94(3): 1269-1278, 2003.



13. Fatemian M, Gamboa A, León-Velarde F, Rivera-Ch M, Palacios J-A, and Robbins P.A. Ventilatory response to CO₂ in high altitude natives and patients with chronic mountain sickness. J. Applied Physiol. 94(3): 1279-1287, 2003.
14. Gamboa J, Macarlupu JL, Rivera-Chira M, Monge-C C, León-Velarde F. Effect of domperidone on ventilation and polycythemia after 5 weeks of chronic hypoxia in rats. Respir Physiolo Neurobiol. 135(1):1-8, 2003.



15. León-Velarde F. Pursuing International recognition of Chronic Mountain Sickness. High Alt. Med. & Biol. 4(2): 256-259, 2003.
16. Brutsaert TD, Parra EJ, Shriver MD, Gamboa A, Palacios JA, Rivera M, Rodriquez I, León-Velarde F. Spanish genetic admixture is associated with larger VO2max decrement from sea level to 4,338 meters in Peruvian Quechua. J Appl Physiol. 95(2) : 519-528, 2003.



17. Maggiorini M, León-Velarde F. High-altitude pulmonary hypertension : a pathophysiological entity to different diseases. Eur Respir J. 22 : 1019-1025, 2003.



18. León-Velarde F, McCullough RG, McCullough RE, Reeves JT; CMS Consensus Working Group. Proposal for scoring severity in chronic mountain sickness (CMS). Background and conclusions of the CMS Working Group. Adv Exp Med Biol. 2003;543:339-54. 



19. Bernardi L, Roach RC, Keyl C, Spicuzza L, Passino C, Bonfichi M, Gamboa A, Gamboa J, Malcovati L, Schneider A, Casiraghi N, Mori A, León-Velarde F. Ventilation, autonomic function, sleep and erythropoietin. Chronic mountain sickness of Andean natives. Adv Exp Med Biol. 2003;543:161-75.
20. Monge C. C. y F. León-Velarde. El Reto Fisiológico de Vivir en los Andes. Tomo 177. Travaux del Institut Francais d'Etudes Andines (IFEA). Editores, IFEA/ Universidad Peruana Cayetano Heredia. Lima, 2003, IFEA/UPCH. p.p. 435.



21. Spicuzza L, Casiraghi N, Gamboa A, Keyl C, Schneider A, Mori A, León-Velarde F, Di Maria GU, Bernardi L. Sleep-related hypoxaemia and excessive erythrocytosis in Andean high-altitude natives. Eur Respir J. 2004; 23(1):41-46.



22. Brutsaert TD, Parra E, Shriver M, Gamboa A, Palacios JA, Rivera M, Rodriguez I, León-Velarde F. Effects of birthplace and individual genetic admixture on lung volume and exercise phenotypes of Peruvian Quechua. Am J Phys Anthropol.  2004; 123(4): 390-398. 



23. Reeves JT and León-Velarde F. Chronic Mountain Sickness: Recent studies of the relationship between hemoglobin concentration and oxygen transport. High Alt. Med and Biol. 2004; 5(2): 147-155.



24. Claydon V.E., L.J. Norcliffe, J.P. Moore, M. Rivera-Ch, F. León-Velarde, O. Appenzeller and R. Hainsworth. Orthostatic tolerance and blood volumes in Andean high altitude dwellers. Exp Physiol. 2004; 89(5): 565-571.



25. Mejia OM, Prchal JT, León-Velarde F, Hurtado A, Stockton DW. Genetic association analysis of chronic mountain sickness in an Andean high-altitude population. Haematologica. 90(1):13-19, 2005.



26. Claydon VE, Norcliffe LJ, Moore JP, Rivera M, León-Velarde F, Appenzeller O, Hainsworth R. Cardiovascular responses to orthostatic stress in healthy altitude dwellers, and altitude residents with chronic mountain sickness. Exp Physiol. 90(1):103-110, 2005. 

1. Oxicapnógrafos
2. Oxímetros
3. Espirómetros
4. Electrocardiógrafos
5. Neumotacógrafos
6. Pletismografo
7. Oxígrafo
8. Espectrofotometro
9. Analizador de gases en sangre