Humberto Guerra    

_______________________________________________________________________________________________________________

TITLE:

Professor, Department of Medicine; Member, Directive Committee Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia.

EDUCATION

POSITIONS HELD:

• Universidad Peruana Cayetano Heredia (UPCH): Medicine: Instructor, 1966; Assist. Prof, 1969; Assoc. Prof, 1971; Full Prof, 1977. Member, Directive Committee, Dept. Medicine, since 1994.

• Founding Member ('68), Instituto de Medicina Tropical "Alexander von Humboldt" (IMT AvH), UPCH. Member Dir. Comm, 1977-on. Deputy Director 1981-'85. Director 1986-'89 & '89-'92; 2 periods, legal limit.

• Director, University Directorate for International and National Relations (DURIN), UPCH, 1997-1999.

• Coordinator, UPCH Committee for Asia Pacific, the UPCH APEC Study Center, a member of the Peruvian Network for Asia Pacific Studies (REDAP), a network of 8 prestigious Academic institutions.

• Coordinator for the UPCH, institutional project on telemedicine and health communication for rural areas, Enlace Hispano Americano de Salud (EHAS - Hispano American Health Link), since 2000.

• Chairman, Institutional Ethics Committee (CIE), UPCH, since 2001.

• Hospital Cayetano Heredia, 1997-'83: Assistant Medical Officer, Inf. & Trop. Diseases Unit, (UCEIT).

• Assist. Director, Health Research Center (CIS) Nac. Inst. Health (INS), 1983-'85. Director, 1985-'90.

• Member, Committee for Scientific Research, Instituto Nacional de Salud (INS, Peruvian NIH), since 1999.

• Member, Ethics Committee, INS, 1999-2002.

• National Council for Science and Technology (CONCYTEC). Committees from '84. Directive Comm. 1991-1997.  CONCYTEC delegate, various international meetings, '90,'93,'94,'97.

• Temporary advisor: PAHO/WHO,'77.'81,'84, '87,'91,'93,'94. CONTACT Berlin,'87. European Union, Europ. Commission, Directorate General XII, Science & Technology for Development: STD2, STD3 '88-'91,'91-'93. 

• Consultant to US AID, Bolivia, on behalf of Environmental Health Research – Subject: Malaria.  Nov 2000.

• American Society for Microbiology (ASM) Ambassador for Perú.  Since 2000.

• Member, National Committee to Celebrate the Bicentennial of the Visit of A. von Humboldt to Perú, 2002.

HONORS AND AWARDS: 

• With Bac.Med. Thesis, "Immunological Studies in Human Brucellosis. Clinical and Bacteriological Considerations": - 3rd Prize in Theses Contest, UPCH, from Merck, Sharp & Dohme, 1966, and - 1st Prize "Hipólito Unanue", Promotion of Culture, Medical Sciences, Casa  Nacional de la Cultura, 1966.

• Awarded a WK Kellogg Foundation Fellowship Jul'67-Jul'69, at Microbiology & Immunology, Baylor College of Medicine, Houston, Texas, U.S.A. Followed with a Fellowship from the same Department, Jul'69-Apr'70.

• With Ph.D. Thesis, "Infection at the Subcellular Level:  Distribution and Fate of Bloodborne Brucellae in Organs and Tissue Phagocytes of Guinea Pigs": 2nd Prize, Instituto Hipólito Unanue, -  - With Doctor of Medicine Thesis, "Brucella melitensis as a Biological Particle.  Properties and Subcellular Infection": 1st Prize, annual Instituto Hipólito Unanue contest, Medical Research, 1972.

• With article on Ampicillin and Pivampicillin levels: Accessory Prize, Tribuna Médica, Perú, 1974.

• With article on human Diphyllobothriasis (co-author): Acc. Prize Inst. H. Unanue, Med. Res., 1976.

• Awarded an Alexander von Humboldt Foundation Research Fellowship at Department of Microbiology and Hygiene, University of Würzburg, Federal Republic of Germany, Dec 1980-Jun 1981.

• Member of National Academies: N.A. of Sciences (ANC) 1990; Associate N.A. of Medicine (ANM) 1990; Full Member, 2000; N.A. Of Science and Technology, 1991; Directive Body 1991-'98 & 1999-2004.

• Member of the Cayetano Heredia Order, Officer Level, 1997.

• “Hugo Lumbreras” Award, UPCH and Asociación Cayetano Heredia, 1998.

• Diploma and Medal, distinguished service in teaching and research, Colegio Médico del Perú, 1999.

• Guest of Honor, Guayaramerín City: Declaration and Diploma, as Consultant to US AID/Bolivia.  Nov 2000.

PUBLICACIONES

PUBLICATIONS IN JOURNALS (out of 57)

• Guerra H, Deter R, Williams RP, 1972. "Infection at the subcellular level: 1. Localization of intravenously injected brucellae in the vacuolar apparatus of cells of guinea pig liver". Infection and Immunity. 5: 515-523.

• Guerra H, Deter R, Williams RP, 1973. "Infection at the subcellular level: 2. Distribution and fate of intravenously injected brucellae within phagocytic cells of guinea pigs". Infection and Immunity. 8: 694-699.

• Guerra H, Montestruque S, 1973. "Estudio comparativo de Pivampicilina y Ampicilina". Tribuna Médica: Perú. 411: 1-8.

• Guerra H, 1973. "Lysosomes in the host-parasite relationship". Acta Phys. Lat.Americ. 23: 661-662.

• Guerra H, 1974. "Morphology of blood, liver and spleen cells from guinea pigs involved in antibacterial defence against brucellae". IRCS (International Research Communications System).- Research on : Biophysics, Membrane and Cell Biology; Hematology; Immunology and Allergy; Microbiology, Parasitology and Infectious Diseases. 2: 1501.

• Guerra H, Vidal C, 1978. "La enseñanza integrada de la Microbiología en la formación médica". Educ. Méd. Salud. 12: 295-307.

• Guerra H, 1979. "Lysosomes versus Brucella melitensis". Rev. Microscopía Electrónica y Biología Celular. 6: 89-96.

• Guerra H, 1979. "Principales defensas contra los microorganismos patógenos". Revista Diagnóstico. 4: 261-266.

• Guerra H, 1982. "Perspectivas en la prevención de las Enfermedades Tropicales". Rev. Sanidad Fuerzas Policiales 43: 78-81.

• Palomino JC, Guerra H, Lumbreras H, 1983. "A selective liquid medium for primary isolation of South American Leishmanias". Tropenmed. Parasitol.  34: 229-232.

• Benavente L, Gotuzzo E, Guerra J, Grados O, Guerra H, Bravo N. 1984. “Diagnosis of typhoid fever using a string capsule device”. Trans. R. Soc. Trop. Med. Hyg. 1984. 78: 404-406.
  Pérez E, Villaseca P, Llanos A, Campos M, Guerra H, 1988. "Técnicas de muestreo de especies de Lutzomyia (Diptera: Psychodidae) utilizadas en ambientes altoandinos del Perú". R. Per. Ent. 29: 87-91.

• Reiner NE, Lo R, Llanos-Cuentas A, Guerra H, Button LL, MacMaster WR, 1989. "Genetic heterogeneity in Peruvian Leishmania isolates". American J. Trop. Medicine and Hygiene. 41: 416-421.

• Pérez JE, Villaseca P, Cáceres A, López M, Zolessi A, Campos M, Guerra H, Llanos-Cuentas A, 1989. "Leishmania (Viannia) peruviana isolated from the sandfly Lutzomyia peruensis (Diptera: Psychodidae) and a sentinel hamster in the Huayllacallán valley (Ancash, Perú)". Transactions of the Royal Society of Tropical Medicine and Hygiene. 85: 60.

• Ogusuku E, Pérez JE, Paz L, Nieto E, Monje J, Guerra H, 1991. "El hombre como fuente de sangre para Lutzomyia spp. (Diptera: Psychodidae) andinos". Rev. Peruana Entomol. 34: 56.

• Palomino JC, Falconí E, Marín D, Guerra H, 1991. "Assessing the viability of Mycobacterium leprae by the fluorescein diacetate/ethidium bromide staining technique. Indian J of Leprosy. 63: 203-208.

• Guerra H, 1992. "Endemias parasitarias del Nuevo Mundo. Una introducción". Acta Andina. 2: 88-92.

• Guerra H, Falconí E, Llanos-Cuentas A, Chang J, 1993. "Investigación en Medicina Tropical y Atención Primaria a la Salud en Perú". Salud Pública de México. 35: 477-486.

• Dujardin JC, Gajendran N, Arévalo J, Llanos-Cuentas A, Guerra H, Gómez J, Arroyo J, De Doncker S, Jacquet D, Hamers R, Le Ray D, 1993. "Karyotype polymorphism and conserved characters in the Leishmania (Viannia) braziliensis complex explored with chromosome-derived probes". Ann, Soc. belge Méd. Trop. 73: 101-118.

• Bermúdez H, Torrico F, Rojas E, Balderrama F, LeRay D, Guerra H, Arévalo J. 1993. "Leishmaniasis in the lowlands of Bolivia; prevalence of the disease in two groups of localities with different settlement ages in Carrasco Tropical". Arch. Inst. Pasteur Tunis. 70: 443-453.

• Dujardin J.C., Llanos-Cuentas A., Cáceres A., Arana M., Dujardin J.P., Guerrini F., Gómez J., Arroyo J., De Doncker S., Jacquet D., Hamers R., Guerra H., Le Ray D., Arévalo J., 1993.  "Molecular karyotype variation in Leishmania (Viannia) peruviana: indication of geographical populations in Perú distributed along a north-south cline".  Ann. Trop. Med. Parasitol.  87: 335-347. 

• Pérez JE, Ogusuku E, Inga R, López M, Monje J, Paz L, Nieto E, Arévalo J, Guerra H, 1994. "Natural Leishmania infection of Lutzomyia spp. in Perú". Transactions of the Royal Society for Tropical Medicine and Hygiene. 88: 161-164.

• Ogusuku E, Pérez JE, Paz L, Nieto E, Monje J, Guerra H. 1994. "Identification of bloodmeal sources of Lutzomyia spp. in Perú". Annals of Tropical Medicine and Parasitology. 88: 329-335.

• Dujardin JC, Dujardin JP, Tibayrenc M, Timperman C, DeDoncker S, Jacket D, Arévalo J, Llanos-Cuentas A, Guerra H, Hamers R, LeRay D. 1995. "Karyotype plasticity in Neotropical Leishmania and indices for measuring genomic distance among L.(V.) peruviana and L.(V.) braziliensis populations". Parasitology. 110: 21-30.

• Franco AA, Yeh PE, Johnson JA, Barry EM, Guerra H, Maurer R, Morris JG. 1996. "Cloning and characterization of dnaE, encoding the catalytic subunit of replicative DNA polymerase III, from Vibrio cholerae strain C67606". Gene. 175: 281-283.

• - Franco A, Fix AD, Prada A, Paredes E, Palomino JC, Wright AC, Johnson JA, McCarter R, Guerra H, Morris JG. 1997. "Cholera in Lima, Perú, correlates with prior isolation of Vibrio cholerae from the environment". American J. Epidemiology.  146: 1067-1075.- Córdova M, Herrera P, Ñopo L, Bellatin J, Náquira C, Guerra H, Espinoza JR. 1997.  "Fasciola hepatica cysteine proteinases: Immunodominant antigens in human fascioliasis".  Am. J.Trop.Med.Hyg.  57: 660-666.

• Birtles RJ, Canales J, Ventosilla P, Alvarez E, Guerra H, Llanos-Cuentas A, Doshi N, Harrison TG.  1999.  "Survey of Bartonella species infecting intra-domicillary animals in the Huayllacallán valley, Ancash, Perú, a region endemic for human bartonellosis".  Am.J.Trop.Med.Hyg.  60: 799-805.

• Raoult D, Birtles RJ, Montoya M, Pérez E, Tissot-Dupont H, Roux V, Guerra H.  1999.  "Survey of three bacterial louse-associated diseases among rural Andean communities in Perú: prevalence of epidemic typhus, trench fever, and relapsing fever".  Clin.Infect.Dis.  29: 434-436.

• Seas C, Alarcón M, Aragón J, Beneit S, Quiñónez M, Guerra H, Gotuzzo E.  2000. "Surveillance of bacterial pathogens associated with acute diarrhea in Lima, Perú".  Int.J.Infect.Dis.  4: 96-99.

• Cardona-Castro N, Gotuzzo E, Rodríguez M, Guerra H.  2000. "Clinical application of a Dot Blot Test for diagnosis of Enteric Fever due to Salmonella enterica Serovar Typhi in patients with Typhoid Fever from Colombia and Perú".  Clin.Diag.Lab.Immun.  7: 312-313.

• Guerra H. 2000. "Development of the Instituto de Medicina Tropical Alexander von Humboldt of the Universidad Peruana Cayetano Heredia, plus some reflections on tropical medicine research in developing countries in the 21st century".  Mem. Inst. Oswaldo Cruz. 95:Suppl.1:43-46.

• Palomino JC, Martin A, Camacho M, Guerra H, Swings J, Portaels F. 2002. Resazurin microtiter assay plate: simple and inexpensive method for detection of drug resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 46: 2720-2722.

• Parola P, Shpynov S, Montoya M, López M, Houpikian P, Zeaiter Z, Guerra H, Raoult D. 2002.  First molecular evidence of new Bartonella spp. in fleas and a tick from Peru. Am.J.Trop.Med.Hyg. 67: 135-136.

PUBLICATIONS IN BOOKS (out of 27)

• Lumbreras H, Guerra H, 1985. "Leishmaniasis in Perú". In Leishmaniasis. KP Chang, L Bray, Eds. Elsevier, North Holland. pp. 297-311.

• Guerra H, 1988. "Distribution of Leishmaniasis in Perú". In Research on Control Strategies for Leishmaniases. BC Walton, PM Wijeyaratne, F Modabber, Editors. IDRC - Manuscript Report 1284e - Ottawa, Canada. pp. 135-147.

• Guerra H, 1988. "Role of national data centers and obligatory reporting in control programs". Ibid. pp. 237-238.

• Guerra H, 1988. "Policy Guidelines of the Health Sector in Perú". In Advanced Training in the Health Professions for Developing Countries. D Warning, P Petit, Editors. Deutsche Stiftung für Internationale Entwicklung (DSE), Berlin (West) 27.

• Lumbreras H, Guerra H, 1989. "Bartonellosis. (Carrión's Disease, Oroya Fever: Anemic Stage, Verruga Peruana: Eruptive Stage)". In Tropical Medicine. R Goldsmith, D Heyneman, Editors. Appleton & Lange, California. pp. 172-174.

• Guerra H, 1990. "El Instituto de Medicina Tropical Alexander von Humboldt. Pasado, Presente y Proyecciones Futuras". In Instituto de Medicina Tropical Alexander von Humboldt (1968-1989). A Zavaleta, Editor. Megaprint Ediciones, Lima. pp. 27-62.

• Guerra H, 1992. "On the Appropriation of Technology - Examples from Leishmaniasis and Health Research". In International Workshop on Leishmaniasis Control Strategies; A critical evaluation of IDRC-supported research. PM Wijeyaratne, T Goodman, C Espinal, Editors. IDRC - Manuscript Report MR322e - Ottawa, Canada. pp. 318-320.

• Guerra H, Benavente L, 1992. "Capítulo XXII. Técnicas simples de laboratorio". In Atención Primaria de Salud. Principios y Métodos. A Kroeger, R Luna, Compiladores. 2a Edición. Organización Panamericana de la Salud, Pax México. pp. 598-624.

• Guerra H, 1993. "Avances en Enfermedades Bacterianas". In Actas de Ciencias y Tecnologías en Biología. Acad. Nac. de Ciencia y Tecnología (ANCYT) & CONCYTEC). Vol 1, No 1. Lima, Perú. pp. 5-9.

• Guerra H, 1994. "Bartonelosis". Cap. 28. In Microbiología. Mecanismos de las enfermedades infecciosas. M Schaechter, G Medoff, BI Eisenstein, H Guerra, Eds. 1st Ed. in Spanish. Edit. Méd. Panam, Bs. Aires. pp. 389-397.

• Guerra H, 1994. "Insecticidas y control biológico de vectores: dos estrategias". In Talleres No. 3. Taller Latino Americano Sobre Control de Vectores. Universidad de los Andes, Consejo de Publicaciones. Mérida, Venezuela. pp. 113-115.

• Ventosilla P, Marín D, Guerra H, 1994. "Mecanismo de acción de bacilos esporulados entomopatógenos". Ibid. pp. 131-133.

• Campos M, Guerra H, 1995. "Health Telematics in Perú". In Health, Information Society and Developing Countries. M. Sosa Iudicissa, J Levett, S Mandil, PF Beales, Eds. Serie Studies in Health Technology and Informatics, Vol. 23. IOS Press, Amsterdam, Oxford, Tokyo, Washington D.C. pp. 93-102.

• Lumbreras H, Guerra H, 1995. "Bartonelosis. (enfermedad de Carrión, fiebre de Oroya-etapa anémica, Verruga Peruana-etapa eruptiva)". In Parasitología y Medicina Tropical. R Goldsmith, D Heyneman, Editors. J Orizaga, MC Franco, MR Carsolio, Trad. El Manual Moderno, México, Bogotá. pp. 226-230.

• Guerra H, Campos M, Benavente L, Chang J, Díaz F, Franchi LM. 1997. Translation of the book: "Field Trials for Health Interventions in Developing Countries. A Toolbox". PG Smith, Richard R Morrow, Eds. Second Ed. (First in Spanish) - Special Programme PNUD/World Bank/WHO for Research and Training in Tropical Diseases (TDR). Commissioned by the Pan American Health Organization, PAHO, 1996.

• Birtles RJ, Canales JJ, Ventosilla P, Alvarez E, Harrison TG, Guerra H, Llanos-Cuentas A, Raoult D.  1996. "Prevalence and genotypic analysis of Bartonella species isolated from intra-domicilliary animals in bartonellosis-endemic regions of Perú". In Rickettsiae and Rickettsial Diseases. Vth International Symposium. Stará Lesná, Sept. 1996, Slovac Republic. J Kazár, R Toman, Eds. Slovac Academy of Sciences, Institute of Virology, Bratislava, Slovac Republic. pp. 611-621.

• Guerra H.  1997.  "Las relaciones internacionales de la Universidad Peruana Cayetano Heredia".  In Universidad Peruana Cayetano Heredia.  XXXV Aniversario.  Impresiones Santa Ana, Lima, Perú 1997.

• Guerra H.  1998.  "Development of the Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia".  In Wissenschaftleraustausch und Entwicklungszusammenarbeit vor der Jahrtausandwende.  Bestandsauname, Probleme und Perpektiven (Cientific Exchange and Cooperation towards the End of the Millennium.  Positions, Problems and Perspectives).  Symposium of the Alexander von Humboldt Foundation, Bonn-Bad Godesberg 1997.  Nomos Verlagsgesellschaft, Baden-Baden.

• Walker DH, Guerra H, Maguiña C.  1999. "Bartonellosis".  In Tropical Infectious Diseases: Principles, Pathogens, and Practice.  GL Guerrant, DH Walker, PF Weller, Eds.  Harcourt Brace & Co., Orlando, Florida. 

• Guerra H., Pérez E., Llanos-Cuentas A.  2000.  "Vector Biology and Control of Leishmaniasis in Perú". 

• In XV International Congress  for Tropical Medicine and Malaria.  Abstract MoS13-3, p 88.  Cartagena, Aug.

EDITORIAL ACTIVITY: Scientific Journals 

• International Advisory Board, Memórias do Instituto Oswaldo Cruz (Rio de Janeiro)

• International Adviser, Annals of Tropical Medicine and Parasitology (Liverpool)

• Editorial Board member, Tropical Medicine and International Health (London – ended December 2000)

• Editorial Board member, Electronic Journal of Pathology and Histology (Hamburg) 

EDITORIAL ACTIVITY: Translations

• Guerra H, responsible for the Spanish Edition of “Mechanisms of Microbial Disease” M. Schaechter, G. Medoff, B.I. Eisenstein,  Second Ed. 1993, Williams & Wilkins, Baltimore, London, etc.:

• “Microbiología. Mecanismos de las enfermedades infecciosas”.  M. Schaechter, G. Medoff, B.I. Eisenstein, H. Guerra, Eds.  First Spanish Ed. 1994, Edit. Méd. Panam., Bs. Aires.

• Guerra H., Campos M., Benavente L., Chang J., Díaz F., Franchi L.M.  1998.  Translators of “Field Trials for Health Interventions in Developing Countries.  A Toolbox”.  P.G. Smith, Richard R. Morrow, Eds. Second Ed. UNDP / WorldBank / WHO Program Special for Research and Training in Tropical Diseases.:

• “Ensayos de campo de intervenciones en salud en países en desarrollo.  Una caja de herramientas”. P.G. Smith, Richard R. Morrow, Eds. 1998, Pan American Health Organization

• Portaels F., Guerra H. 2002. Responsible for the Spanish version of “Ulcère de Buruli”. 2000. Guédenon A., Portaels F., Aguiar J., Cissé L., Debacker M., Meyers W.M., Zinsou C. Institut de Médedine Tropicale, Antwerp, Belgium:

• “Úlcera de Buruli (Infección por Mycobacterium ulcerans)”. Portaels F., Guédenon A., Aguiar J., Debacker M., Meyers W.M., Guerra H., Falconí E, Palomino J.C. 2002. Instituto de Medicina Tropical, Amberes, Bélgica.

LECTURES ON INTERNET  

Lectures  “Malaria in the Peruvian Jungle”, "Anthrax" and “Anthrax II - The Sequel” . Global Health Network, Epidemiology Supercourse, 1998, 2000 and 2002, respectively:

URL > "Malaria" > http://www.pitt.edu/~super1/lecture/lec0172/   

URL > "Anthrax" > http://www.pitt.edu/~super1/lecture/lec1221/   

PUBLISHED LETTERS

• Benavente L, Gotuzzo E, Guerra J, Grados O, Guerra H.Diagnosis of Salmonella typhi by culture of duodenal string capsule. N Engl J Med 1981 Jan 1;304(1):54 - Letter

Marzo, 2003